The Molecular Mycology Laboratory

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1. Coelho MA, Ianiri G, David-Palma M, Theelen B, Goyal R, Narayanan A, Lorch JM, Sanyal K, Boekhout T, Heitman J (2023) Frequent transitions in mating-type locus chromosomal organization in Malassezia and early steps in sexual reproduction. PNAS PDF 

2. Singha R, Aggarwal R, Sanyal K* (2023) Negative regulation of biofilm development by the CUG-Ser1 clade-specific histone H3 variant is dependent on the canonical histone chaperone CAF1 complex in Candida albicans. Molecular Microbiology (in press)

3. Narayanan A^, Kumar P^, Chauhan A, Kumar M, Yadav K, Banerjee A, Sharma RD, Rudramurthy SM, Chakrabarti A, Sanyal K*, Prasad R*  (2022) Directed evolution detects supernumerary centric chromosomes conferring resistance to azoles in Candida auris. mBio PDF  

4. Jaitly P, Legrand M, Das A, Patel T, Chauvel M, Maufrais C, d’Enfert C*, Sanyal K* (2022) A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans. Nature Communications  PDF     Recommended by F1000  

5. Narayanan A*, Selvakumar P, Siddharthan R, Sanyal K* (2022) ClaID: A rapid method of clade-level identification of the multidrug-resistant human fungal pathogen Candida auris. Microbiology Spectrum PDF

6. Panchal S*, Sanyal K* (2022) Loss of nucleosome assembly protein 1 affects growth and appressorium structure in blast fungus Magnaporthe oryzae. microPublication Biology PDF

7. Rudramurthy S, Kashyap N, Bhattacharya S, Soman R, Shankarnarayan S, Chavan D, Singh S, Das P, Kaur H, Ghosh A, Prasad S, Sanyal K, and Chakrabarti A (2022) Impact of FKS1 genotype on echinocandin in-vitro susceptibility in Candida auris and in-vivo response in a murine model of infection. Antimicrobial Agents and Chemotherapy PDF

8. Mehta G, Sanyal K, Abhishek S, Rajakumara E, Ghosh SK (2022) Minichromosome maintenance proteins in eukaryotic chromosome segregation. BioEssays PDF

9. Padmanabhan S, Sanyal K*, Dubey DD* (2021) Identification and in silico analysis of the origin recognition complex in the human fungal pathogen Candida albicans. microPublication Biology PDF

10. Sane A, Sridhar S, Sanyal K, Ghosh SK (2021) Shugoshin ensures maintenance of the spindle assembly checkpoint response and efficient spindle disassembly. Molecular Microbiology PDF

11. Chatterjee S, Som S, Varshney N, Satyadev PVS, Sanyal K, Paul R (2021) Mechanics of microtubule organizing center clustering and spindle positioning in budding yeast Cryptococcus neoformans. Physical Review E PDF

12. Reza H*, Patkar R*, Sanyal K* (2021) Vacuolar transporter Mnr2 safeguards organellar integrity in aged cells. Molecular Microbiology PDF

13. Narayanan A, Vadnala RN, Ganguly P, Selvakumar P, Rudramurthy SM, Prasad R, Chakrabarti A, Siddharthan R, Sanyal K* (2021) Functional and comparative analysis of centromeres reveals clade-specific rearrangements in Candida auris and a chromosome number change in related species. mBio. PDF                                                                                                                                                                                                                                    Commentary I Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen Candida auris and Its Relatives. mBio. PDF  Commentary I The curious case of nonrepetitive centromeric DNA sequences in Candida auris and related species . mBio. PDF

14. Sreekumar L, Kumari K, Guin K, Bakshi A, Varshney N, Thimmappa BC, Narlikar L, Padinhateeri R, Siddharthan R, Sanyal K* (2021) Orc4  spatiotemporally stabilizes centromeric chromatin. Genome Research. PDF

15. Sridhar S, Hori T, Nakagawa R, Fukagawa T*, Sanyal K* (2021) Bridgin connects the outer kinetochore to centromeric chromatin. Nature Communications. PDF  Recommended by F1000  

16. Guin K^*, Sreekumar L^*, Sanyal K* (2020) Implications of the evolutionary trajectory of centromeres in the fungal kingdom. Annual Review of Microbiology.  PDF; Invited Review

17. Guin K, Chen Y, Mishra R, Siti R, Thimmappa BC, O'Brien C, Butler G, Sanyal A*, Sanyal K* (2020) Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres. eLIFE.  PDF  Recommended by F1000  

18. Fang YF, Coelho MA, Sue H, Schotanus K, Thimmappa BC, ...., Sanyal K, Dong S, Nowrousian M, Heitman J  (2020) Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. PLOS Genetics.  PDF

19. Sankaranarayanan SR, Ianiri G, Coelho M, Reza H, Thimmappa BC, Ganguly P, Vadnala RN, Sun S, Siddharthan R, Tellgren-Roth C, Dawson TL, Heitman J*, Sanyal K* (2020) Loss of centromere function drives karyotype evolution in closely related Malassezia species. eLIFE. PDF                                                      eLife digest The yeast that re-organized its centromeres 

20. Navarro-Mendoza M, Perez-Arques C, Panchal S, Nicolas FE, Mondo SJ, Ganguly P, Pangilinan J, Grigoriev IV, Heitman J*, Sanyal K* and Garre V* (2019) Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres. Current Biology.  PDF Recommended by F1000  ;   Commentary I  Evolution: A mosaic-type centromere in an early diverging fungus. Current Biology. PDF

21. Rai LS, Singha R, Sanchez H, Chakraborty T, Chand B, Bachellier-Bassi S, Chowdhury S, d’Enfert C, Andes DR, Sanyal K* (2019) The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation, PLOS Biology.  PDF  Recommended by F1000  

22. Yadav V^, Yang F^, Reza H, Liu S, Valent B, Sanyal K*, Naqvi NI* (2019) Cellular dynamics and genomic identity of centromeres in cereal blast fungus, mBIO. PDF

23. Prasad P, Sanyal K, Ghosh SK (2019) Sth1, the key subunit of the RSC chromatin remodeling complex, is essential in maintaining chromosomal integrity and mediating high fidelity chromosome segregation in the human fungal pathogen Candida albicans,  Frontiers in Microbiology.   PDF

24. Varshney N*, Sanyal K* (2019) Nuclear migration in budding yeasts: position before division, Current Genetics.  PDF; Invited Review

25. Sreekumar L, Jaitly P, Chen Y, Thimmappa BC, Sanyal A, Sanyal K* (2019) Cis and trans chromosomal interactions define pericentric boundaries in the absence of conventional heterochromatin, Genetics.  PDF

26. Suneet K^, Sridhar S^, Agiwal P, Sridhar MS, Sanyal K, Jain S (2019) Magnetic hyperthermia adjunctive therapy for fungi: in vitro studies against Candida albicans,  International Journal of Hyperthermia.  PDF

27. Varshney N, Sanyal K* (2019) Aurora kinase Ipl1 facilitates bilobed distribution of clustered kinetochores to ensure error‐free chromosome segregation in Candida albicans, Molecular Microbiology. PDF

28. Legrand M, Jaitly P, Feri A, d’Enfert C*, Sanyal K* (2019) Candida albicans: an emerging yeast model to study eukaryotic genome plasticity, Trends in Genetics. PDF; Invited Review

29. Varshney N, Som S^, Chatterjee S^, Sridhar S, Bhattacharyya D, Paul R*, Sanyal K* (2019) Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans, PLOS Genetics. PDF

30. Kakade P, Mahadik K, Balaji KN, Sanyal K, Nagaraja V (2019) Two negative regulators of biofilm development exhibit functional divergence in conferring virulence potential to Candida albicans, FEMS Yeast Research. PDF

31. Hoque J, Yadav V, Prakash RG, Sanyal K, Haldar J (2018) Dual-Function Polymer–Silver Nanocomposites for Rapid Killing of Microbes and Inhibiting Biofilms, ACS Biomaterials Science & Engineering. PDF

32. Yadav V, Sreekumar L, Guin K, Sanyal K* (2018) Five pillars of centromeric chromatin in fungal pathogens, PLOS Pathogens. PDF Invited Review

33. Yadav V*, Sanyal K* (2018) Sad1 spatiotemporally regulates kinetochore clustering to ensure high-fidelity chromosome segregation in the human fungal pathogen Cryptococcus neoformans, mSphere.  PDF

34. Yadav V, Sun S, Billmyre RB, Thimmappa BC, Shea T, Lintner R, Bakkeren G, Cuomo CA, Heitman J, Sanyal K* (2018) RNAi is a critical determinant of centromere evolution in closely related fungi, PNAS. PDF

35. Rai LS, Singha R, Brahma P, Sanyal K*. (2018) Epigenetic determinants of phenotypic plasticity in Candida albicans, Fungal Biology Reviews. PDF;  Invited Review

36. Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, Wang L, Souciet JL, Boekhout T, Porcel B, Wincker P, Granek JA, Sanyal K, Heitman J. (2017) Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination, PLOS Biology. PDF

37. Altamirano S, Fang D, Simmons C, Sridhar S, Wu P, Sanyal K, Kozubowski L. (2017) Fluconazole-induced ploidy change in Cryptococcus neoformans results from the uncoupling of cell growth and nuclear division, mSphere. PDF; Recommended by F1000  

38. Ghosh C, Yadav V, Younis W, Mohammad H, Hegazy YA, Seleem MN, Sanyal K, Haldar J. (2017) Aryl-alkyl-lysines: membrane-active fungicides that act against biofilms of Candida albicans, ACS Infectious Diseases. PDF

39. Zhu Y, Engström PG, Tellgren-Roth C, Baudo CD, Kennell JC, Sun S, Billmyre RB, Schröder MS, Sankaranarayanan SR, Sanyal K, Andersson A, Holm T, Sigurgeirsson B. (2017) Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. Nucleic Acids Research. PDF

40. Hoque J, Adhikary U, Yadav V, Samaddar S, Konai MM, Prakash RG, Paramanandham K, Shome BR, Sanyal K, Haldar J. (2016) Chitosan derivatives active against multidrug-resistant bacteria and pathogenic fungi: in vivo evaluation as topical antimicrobials, Molecular Pharmaceutics. PDF

41. Datta A^, Yadav V^, Ghosh A, Choi J, Bhattacharyya D, Kar RK, Ilyas H, Dutta A, An E, Mukhopadhyay J, Sanyal K, Lee D, Ramamoorthy, A Bhunia A (2016) Mode of action of a designed antimicrobial peptide: high potency against Cryptococcus neoformans, Biophysical Journal. PDF

42. Kakade P, Sadhale P, Sanyal K, Nagaraja V. (2016) ZCF32, a fungus-specific Zn (II) 2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans, Scientific Reports. PDF

43. Chatterjee G, Sankaranarayanan SR, Guin K, Thattikota Y, Padmanabhan S, Siddharthan R, Sanyal K* (2016) Repeat-associated fission yeast-like regional centromeres in the ascomycetous budding yeast Candida tropicalis, PLOS Genetics. PDF

44. Mitra S, Rai LS, Chatterjee G, Sanyal K* (2016) Chromatin immunoprecipitation (ChIP) assay in Candida albicans, Methods in Molecular Biology.  PDF

45. Suryanarayanan TS, Gopal V, Sahal D and Sanyal K (2015) Establishing a national fungal genetic resource to enhance the bioeconomy, Current Science. PDF

46. Sutradhar S^ Yadav V^, Sridhar S^, Sreekumar L, Bhattacharyya D, Ghosh SK, Paul R* and Sanyal K* (2015) A comprehensive model to predict mitotic division in budding yeasts, Molecular Biology of the Cell. PDF 

47. KT Nishant* and Sanyal K* (2015) The good, the bad and the ugly: How to protect genome stability from potential threats, Bioessays. PDF Meeting Highlights

48. Varshney N^, Schakel A^, Singha R, Chakraborty T, Wijlick LV, Ernst JF* and Sanyal K* (2015),  A surprising role for the Sch9 protein kinase in chromosome segregation in Candida albicans, Genetics.  PDF

49. Hoque J, Akkapeddi P, Yadav V, Manjunath GB, Uppu DSSM, Konai MM, Yarlagadda V, Sanyal K and Haldar J (2015) Broad-spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship and membrane-active mode of action, ACS Appl. Mater. Interfaces.   PDF

50. Mitra S, Gomez-Raja J, Larriba G, Dubey DD and Sanyal K* (2014) Rad51-Rad52 mediated maintenance of centromeric chromatin in Candida albicans, PLOS Genetics. PDF

51. Janbon G, Ormerod KL, Paulet D, Byrnes III EJ, Yadav V, Chatterjee G, (+41 authors), Sanyal K, Heitman J, Fraser JA, Cuomo CA and Dietrich FS (2014) Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation, PLOS Genetics. PDF; Recommended by F1000  

52. Kozubowski L^, Yadav V^, Chatterjee G, Sridhar S, Yamaguchi M, Kawamoto S, Bose I, Heitman J and Sanyal K* (2013) Ordered kinetochore assembly in the human fungal pathogen basidiomycetous yeast Cryptococcus neoformans, mBIO. PDF

53. Chakraborty U, Mohamed A, Kakade P, Mugasimangalam R, Sadhale PP and Sanyal K* (2013) A stable hybrid containing haploid genomes of two obligate diploid Candida species, Eukaryotic Cell.   PDF

54. Thakur J and Sanyal K* (2013) Efficient neocentromere formation is suppressed by gene conversion to maintain centromere function at native physical chromosomal loci in Candida albicans, Genome Research. PDF

55. Roy B, Varshney N, Yadav V and Sanyal K* (2013) The process of kinetochore assembly in yeasts, FEMS Microbiology Letters. PDF  Invited Review

56. Thakur J and Sanyal K* (2012) A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans, PLOS Genetics. PDF

57. Sanyal K* (2012) How do microbial pathogens make CENs?, PLOS Pathogens. PDF Invited Review

58. Laha S, Das SP, Hajra S,  Sanyal K  and Sinha P (2011) Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest, BMC Genetics. PDF

59. Roy B and Sanyal K* (2011) Diversity in Requirement of Genetic and Epigenetic Factors for Centromere Function in Fungi, Eukaryotic Cell. PDF  Invited Review

60. Thakur J and Sanyal K* (2011) The essentiality of the fungus specific Dam1 complex is correlated with one kinetochore one microtubule interaction present throughout the cell cycle, independent of the nature of a centromere, Eukaryotic Cell. PDF

61. Roy B, Burrack LS, Lone MA, Berman J and Sanyal K* (2011) CaMtw1, a member of the evolutionarily conserved Mis12 kinetochore protein family, is required for efficient inner kinetochore assembly in the pathogenic yeast Candida albicans, Molecular Microbiology. PDF

62. Padmanabhan S^, Thakur J^, Siddharthan R and Sanyal K* (2008) Rapid evolution of Cse4p-rich centromeric DNA sequences in closely-related pathogenic yeasts, Candida albicans and Candida dubliniensis, PNAS.  PDF  Recommended by F1000  

63. Baum M^, Sanyal K^, Mishra PK, Thaler N and Carbon J (2006) Formation of functional centromeric chromatin is specified epigenetically in Candida albicans, PNAS.  PDF; Recommended by F1000   

64. Sanyal K, Baum M and Carbon J (2004) Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique, PNAS.  PDF

65. Sanyal K and Carbon J (2002) The CENP-A homolog CaCse4p in the pathogenic yeast Candida albicans in a centromere protein essential for chromosomes transmission, PNAS. PDF

66. Ghosh SK, Poddar A, Hajra S, Sanyal K and Sinha P (2001) The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation, Molecular Genetics and Genomics.   PDF

67. Sanyal K, Ghosh SK and Sinha P (1998) The MCM16 gene of the yeast Saccharomyces cerevisiae is required for chromosome segregation, Molecular and General Genetics.  PDF                                                                                                                                                                                                                         ^ Equally contributed;  *Corresponding author​

US Patent

Sanyal K, Padmanabhan S, Thakur J (2014) Polynucleotide sequences of Candida dubliniensis and probes for its detection.  

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